Antipsoriatic activity and Cytotoxicity of ethanolic extract of Psoralia corylifolia seeds

Plan: Traditionally in India and China, Psoralia corylifolia seed decoction used for treating psoriasis. However, the antipsoriatic activity of Psoralia corylifolia seeds has not been scientifically evaluated using mouse tail model. Methodology: Ethanolic extract of Psoralia corylifolia seeds were analyzed by high performance thin layer chromatography (HPTLC) .The In vivo antipsoriatic activity of 95% of ethanolic extract of Psoralia corylifolia seeds was done by using mouse tail model for psoriasis and In vitro antipsoriatic activity was carried out by Sulphorhodamine B (SRB) assay using HaCaT human keratinocyte cell lines. Outcome: HPTLC fingerprinting revealed the presence of gallic acid. The ethanolic extract shown IC50 255 μg/ml, with good antiproliferant activity when compared with Asiaticoside as positive control with potent IC50 value of 20.13 μg/ml. Psoralia corylifolia seed extract showed an overall antipsoriatic activity of 75.87%, when compared with standard tazarot gel activity 87.94% by using mouse tail model, confirmed its traditional use in psoriasis treatment.